UBC PiMS Research Group
Pharmacoepidemiology in Multiple Sclerosis Research Group

Yinshan Zhao

Yinshan Zhao

Role:  Statistician / Research Associate

Previous Academic Training: PhD in Statistics (University of British Columbia), MA in Statistics (York University), BSc in Information Science and Management (University of Science and Technology of China)

Current projects: long-term benefits and adverse effects of beta-interferon for multiple sclerosis, prodromal multiple sclerosis

Email: yinshan at mail dot ubc dot ca

 Peer-reviewed Articles

  1. Zhang T, Shirani A, Zhao Y, Karim ME, Gustafson P, Petkau J, Evans C, Kingwell E, van der Kop ML, Zhu F, Oger J, Tremlett H.  Exposure to beta-interferon and onset of secondary progressive multiple sclerosis. Eur J Neurol.  (Accepted)
  2. Lu E, Zhu F, Zhao Y, van der Kop M, Synnes A, Dahlgren L, Sadovnick AD, Traboulsee A, Tremlett H. Birth outcomes of pregnancies fathered by men with multiple sclerosis. Mult Scler. (Epub ahead of print) doi: 1177/1352458514521308
  3. Jing D*, Zhao Y*, Li DKB, Petkau, AJ, Riddehough A, Cutter G, Traboulsee A. Further investigation of safety monitoring guidelines based on magnetic resonance imaging lesion activity in multiple sclerosis clinical trials. Mult Scle. (Epub ahead of print) doi: 10.1177/1352458514533846. (*These authors contributed equally to the manuscript.)
  4. Riddell CA, Zhao Y, Petkau AJ. An adaptive clinical trials procedure for a sensitive subgroup examined in the multiple sclerosis context. Stat Methods Med Res. (Epub ahead of print) doi:10.1177/0962280213480576.
  5. Evans C, F Zhu, Kingwell E, Shirani A, van der Kop ML, Petkau J, Gustafson P, Zhao Y, Traboulsee T, Oger J, Tremlett H. Association between beta-interferon exposure and hospital events in multiple sclerosis. Phamaceopidem Dr S. 2014; 23:1213-1222.
  6. Karim MD, Gustafson P, Petkau J, Y Zhao, Shirani A, Kingwell E, Evans C, van der Kop M, Oger J, Tremlett H. Marginal structural Cox models for estimating the association between b-interferon exposure and disease progression in a multiple sclerosis cohort. J. Epidemiol. 2014; 180:160-171.
  7. Shirani A, Zhao Y, Karim ME, Petkau J, Gustafson P, Evans C, Kingwell E, van der Kop ML, Oger J, Tremlett H. Investigation of heterogeneity in the association between interferon beta and disability progression in multiple sclerosis: an observational study. Eur J Neurol. 2014; 21:835-844.
  8. Lu E, Zhu F, Zhao Y, van der Kop M, Synnes A, Dahlgren L, Sadovnick AD, Traboulsee A, Tremlett H. Birth outcomes in newborns fathered by men with multiple sclerosis exposed to disease modifying drugs. CNS Drugs. 2014; 28:475-482.
  9. Kang, H, LM Metz, AL Traboulsee, M Eliasziw, GJ Zhao, Y Cheng, Y Zhao et al. Application and a proposed modification of the 2010 McDonald criteria for the diagnosis of multiple sclerosis in a Canadian cohort of patients with clinically isolated syndromes. Mult Scler. 2014; 20:458-463.
  10. Zhao Y, Li DKB, Petkau AJ, Riddehough A, Traboulsee A. Detection of unusual increases in MRI lesion counts in individual multiple sclerosis patients. J Am Stat Assoc. 2014; 109:119-132.
  11. Traboulsee AL, Knox KB, Machan L, Zhao Y, Yee I, Rauscher A, Klass D, Szkup P, Otani R, Kopriva D, Lala S, Li DK, Sadovnick D. Prevalence of extracranial venous narrowing on catheter venography in people with multiple sclerosis, their siblings, and unrelated healthy controls: a blinded, case-control study. Lancet. 2014; 383:138-145.
  12. Lu E, Zhao Y, Dahlgren L, Preston R, van der Kop M, Synnes A, Sadovnick AD, Traboulsee A, Tremlett H. Obstetrical epidural and spinal anesthesia in multiple sclerosis. J Neurol. 2013; 260:2620-2628.
  13. Menon S, Shirani A, Zhao Y, Oger J, Traboulsee A, Freedman MS, Tremlett H, Characterising aggressive multiple sclerosis. JNNP. 2013; 84:1192-1198.
  14. Lu E, Zhao Y, Zhu F, van der Kop M, Synnes A, Dahlgren L, Sadovnick AD, Sayao AL, Tremlett H. Birth hospitalization in mothers with multiple sclerosis and their newborns. Neurology. 2013; 80:447-452.
  15. Evans C, Kingwell E, Zhu F, Oger J, Zhao Y, Helen Tremlett. Hospital admissions and multiple sclerosis: a retrospective, observational study examining temporal trends in a Canadian cohort. Am J Manag Care. 2012; 18:735-742.
  16. Shirani A, Zhao Y, Karim ME, Evans C, Kingwell E, van der Kop ML, Oger J, Gustafson P, Petkau J, Tremlett H. Association between use of interferon beta and progression of disability in patients with multiple sclerosis. JAMA. 2012; 308:247-256.
  17. Tremlett H, Feng Z, Petkau J, Oger J, Zhao Y. Natural, innate improvements in multiple sclerosis disability. Mult Scler. 2012; 18:1412-1421.
  18. Kingwell E, van der Kop M, Zhao Y, Shirani A, Zhu F, Oger J, and Tremlett H. Relative mortality and survival in multiple sclerosis: findings from British Columbia, Canada. JNNP. 2012; 83:61-66.
  19. Martin N, Malfair D, Zhao Y, Li D, Traboulsee A, Lang D, Vertinsky AT. Comparison of MERGE and axial T2-weighted fast spin-echo sequences for detection of multiple sclerosis lesions in the cervical spinal cord. Am J Roentgenol. 2012; 199:157-162.
  20. Shirani A, Zhao Y, Kingwell E, Rieckmann P, Tremlett H, Temporal trends of disability progression in multiple sclerosis: findings from British Columbia, Canada (1975-2009). Mult scler, 2012; 18:442-450.
  21. Riddell C*, Zhao Y*, Li DKB, Petkau, AJ, Riddehough A, Cutter G, Traboulsee A. Evaluation of safety monitoring guidelines based on MRI lesion activity in multiple sclerosis. 2011; 77: 2089-2096. (*These authors contributed equally to the manuscript.)
  22. Zhang Y, Traboulsee A, Zhao Y, Metz LM, Li DK, Texture analysis differentiates persistent and transient T1 black holes at acute onset in multiple sclerosis: a preliminary study. Mult Scler. 2011; 17:532-540.
  23. Zhao Y, Petkau AJ, Traboulsee A, Riddehough A, Li KBD. Does MRI lesion activity regress in secondary-progressive multiple sclerosis? Mult Scler. 2010; 16:434-442.
  24. Tremlett H, Zhao Y, Rieckmann P, Hutchinson M. New perspectives in the natural history of multiple sclerosis. Neurology, 2010; 74:2004-2015.
  25. Laule C, Vavasour, IM, Zhao Y, Traboulsee AL, Oger J, Vavasour JD, Mackay AL, Phil D, Li DKB. Two year study of cervical cord volume and myelin water in primary progressive multiple sclerosis. Mult Scler. 2010; 16:670-677.
  26. Koch M, Zhao Y, Yee I, Guimond C, Kingwell E, Rieckmann P, Sadovnick D, Tremlett H. Disease onset in familial and sporadic primary progressive multiple sclerosis. Mult scler. 2010; 16:694-700.
  27. Tremlett H, Yousefi M, Devonshire V, Rieckmann P, Zhao Y. The impact of multiple sclerosis relapses on progression diminishes with time. Neurology. 2009; 73:1616-1623.
  28. Tremlett H, Zhao Y, Devonshire V. Natural history comparisons of primary and secondary progressive multiple sclerosis reveals differences and similarities. J Neurol, 2009; 256:374-381.
  29. Zhao Y, Traboulsee A, Petkau AJ, Li D. Regression of new gadolinium enhancing lesion activity in relapsing-remitting multiple sclerosis. Neurology. 2008; 70:1092-1097.
  30. Tremlett H, Zhao Y, Devonshire V. Natural history of secondary-progressive multiple sclerosis. Mult Scler. 2008; 14:314-324.
  31. Zhao Y and Joe H. Inferences for odds ratio with dependent pairs. Test. 2008; 17:101-119.
  32. Tremlett H, Zhao Y, Joseph J, Devonshire V. Relapses in multiple sclerosis are age and time-dependent. JNNP. 2008; 79: 1368 – 1374.
  33. Dvorak M, Fisher CG, Aarabi B, Harris MB, Hurbert RJ, Rampersaud YR, Vaccaro A, Harrop JS, Nockels RP, Madrazo IN, Schwartz D, Kwon BK, Zhao Y, Fehlings MG. Clinical outcomes of 90 isolated unilateral facet fractures, subluxations, and dislocations treated surgically and nonoperatively. Spine. 2007; 32: 3007-3013.
  34. Elgafy H, Fisher C, Zhao Y, Li M, Boyd M, Kwon BK, Dvorak MF. The radiographic failure of single segment posterior cervical instrumentation in traumatic cervical flexion distraction injuries. Topics in Spinal Cord Injury Rehabilitation.. 2006; 12: 20-29.
  35. Tremlett H, Seemuller S, Zhao Y, Yoshida EM, Oger J. Liver test abnormalities in multiple sclerosis: findings from placebo treated patients. 2006; 67: 1291-1293.
  36. Zhao Y and Joe H. Composite likelihood estimation in multivariate data analysis. Can J of Stat. 2005; 33: 335-356.
  37. Zhao Y, Kumar RA, Baser ME, Evans DG, Wallace A, Kluwe L, Mautner VF, Parry DM , Rouleau GA, Joe H, Friedman JM. Intrafamilial correlation of clinical manifestations in neurofibromatosis 2 (NF2). Genet Epidemiol. 2002; 3: 245-259.

 

Letter to the Editior/Correspondence

  1. Bernales CQ, Ross JP, Lee JD, Zhao Y, Sadovnick AD, Traboulsee AL, Vilarino-Guell C. Progressive multiple sclerosis does not associate with rs996343 and rs2046748. Mult Scler. 2014; 20:766-767.
  2. Shirani A, Zhao Y, Karim ME, Evans C, Kingwell E, van der Kop ML, Oger J, Gustafson P, Petkau J, Tremlett H. Long-Term Effectiveness of the Beta-Interferons in Multiple Sclerosis. JAMA Neurology. 2013; 70:651-653.
  3. Tremlett H, Zhao Y, Devonshire V. Defining the natural history of MS: the need for complete data and rigorous definitions. Mult Scler, 2008; 14: 1142-1143

 

Dissertation

  1. Statistical modelling and inference for discrete and censored familial data. Vancouver, Canada: University of British Columbia. 2004. Supervisor: Harry Joe.

 

Online Resource

  1. Zhao Y and Kondo Y. Fit negative binomial mixed-effect regression model (V1.2). 2013;

http://cran.r-project.org/web/packages/lmeNB

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